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Protocol for a multicentre randomised controlled trial of early and sustained prophylactic hypothermia in the management of traumatic brain injury.

Identifieur interne : 002949 ( Main/Exploration ); précédent : 002948; suivant : 002950

Protocol for a multicentre randomised controlled trial of early and sustained prophylactic hypothermia in the management of traumatic brain injury.

Auteurs : Alistair Nichol [Australie] ; Dashiell Gantner [Australie] ; Jeffrey Presneill [Australie] ; Lynnette Murray [Australie] ; Tony Trapani [Australie] ; Stephen Bernard [Australie] ; Peter Cameron [Australie] ; Gilles Capellier [France] ; Andrew Forbes [Australie] ; Colin Mcarthur [Australie] ; Lynette Newby [Nouvelle-Zélande] ; Stephen Rashford [Australie] ; Jeffrey V. Rosenfeld [Australie] ; Tony Smith [Nouvelle-Zélande] ; Michael Stephenson [Australie] ; Dinesh Varma [Australie] ; Tony Walker [Australie] ; Steve Webb [Australie] ; D James Cooper [Australie]

Source :

RBID : pubmed:26017126

Descripteurs français

English descriptors

Abstract

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Prophylactic hypothermia is effective in laboratory models, but clinical studies to date have been inconclusive, partly because of methodological limitations. Our Prophylactic Hypothermia Trial to Lessen Traumatic Brain Injury (POLAR) randomised controlled trial is currently underway comparing early, sustained hypothermia versus standard care in patients with severe TBI. We describe our study protocol and the challenges in conducting prophylactic hypothermia research in TBI.

PubMed: 26017126


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<name sortKey="Rosenfeld, Jeffrey V" sort="Rosenfeld, Jeffrey V" uniqKey="Rosenfeld J" first="Jeffrey V" last="Rosenfeld">Jeffrey V. Rosenfeld</name>
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<name sortKey="Smith, Tony" sort="Smith, Tony" uniqKey="Smith T" first="Tony" last="Smith">Tony Smith</name>
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<nlm:affiliation>Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand.</nlm:affiliation>
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<name sortKey="Stephenson, Michael" sort="Stephenson, Michael" uniqKey="Stephenson M" first="Michael" last="Stephenson">Michael Stephenson</name>
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<wicri:noRegion>VIC</wicri:noRegion>
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<name sortKey="Varma, Dinesh" sort="Varma, Dinesh" uniqKey="Varma D" first="Dinesh" last="Varma">Dinesh Varma</name>
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<wicri:noRegion>VIC</wicri:noRegion>
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<name sortKey="Walker, Tony" sort="Walker, Tony" uniqKey="Walker T" first="Tony" last="Walker">Tony Walker</name>
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<nlm:affiliation>Department of Intensive Care, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Intensive Care, Royal Brisbane and Women's Hospital, Brisbane, QLD</wicri:regionArea>
<wicri:noRegion>QLD</wicri:noRegion>
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<name sortKey="Webb, Steve" sort="Webb, Steve" uniqKey="Webb S" first="Steve" last="Webb">Steve Webb</name>
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<nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC</wicri:regionArea>
<wicri:noRegion>VIC</wicri:noRegion>
</affiliation>
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<name sortKey="Cooper, D James" sort="Cooper, D James" uniqKey="Cooper D" first="D James" last="Cooper">D James Cooper</name>
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<nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.</nlm:affiliation>
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<title level="j">Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine</title>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Adult</term>
<term>Brain Injuries (therapy)</term>
<term>Critical Care</term>
<term>Emergency Medical Services</term>
<term>Humans</term>
<term>Hypothermia, Induced (methods)</term>
<term>Multicenter Studies as Topic</term>
<term>Outcome Assessment (Health Care)</term>
<term>Research Design</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adulte</term>
<term>Humains</term>
<term>Hypothermie provoquée ()</term>
<term>Lésions encéphaliques ()</term>
<term>Plan de recherche</term>
<term>Services des urgences médicales</term>
<term>Soins de réanimation</term>
<term>Études multicentriques comme sujet</term>
<term>Évaluation de résultat (soins)</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en">
<term>Hypothermia, Induced</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en">
<term>Brain Injuries</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Critical Care</term>
<term>Emergency Medical Services</term>
<term>Humans</term>
<term>Multicenter Studies as Topic</term>
<term>Outcome Assessment (Health Care)</term>
<term>Research Design</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte</term>
<term>Humains</term>
<term>Hypothermie provoquée</term>
<term>Lésions encéphaliques</term>
<term>Plan de recherche</term>
<term>Services des urgences médicales</term>
<term>Soins de réanimation</term>
<term>Études multicentriques comme sujet</term>
<term>Évaluation de résultat (soins)</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Prophylactic hypothermia is effective in laboratory models, but clinical studies to date have been inconclusive, partly because of methodological limitations. Our Prophylactic Hypothermia Trial to Lessen Traumatic Brain Injury (POLAR) randomised controlled trial is currently underway comparing early, sustained hypothermia versus standard care in patients with severe TBI. We describe our study protocol and the challenges in conducting prophylactic hypothermia research in TBI.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Australie</li>
<li>France</li>
<li>Nouvelle-Zélande</li>
</country>
<region>
<li>Bourgogne-Franche-Comté</li>
<li>Franche-Comté</li>
</region>
<settlement>
<li>Besançon</li>
</settlement>
</list>
<tree>
<country name="Australie">
<noRegion>
<name sortKey="Nichol, Alistair" sort="Nichol, Alistair" uniqKey="Nichol A" first="Alistair" last="Nichol">Alistair Nichol</name>
</noRegion>
<name sortKey="Bernard, Stephen" sort="Bernard, Stephen" uniqKey="Bernard S" first="Stephen" last="Bernard">Stephen Bernard</name>
<name sortKey="Cameron, Peter" sort="Cameron, Peter" uniqKey="Cameron P" first="Peter" last="Cameron">Peter Cameron</name>
<name sortKey="Cooper, D James" sort="Cooper, D James" uniqKey="Cooper D" first="D James" last="Cooper">D James Cooper</name>
<name sortKey="Forbes, Andrew" sort="Forbes, Andrew" uniqKey="Forbes A" first="Andrew" last="Forbes">Andrew Forbes</name>
<name sortKey="Gantner, Dashiell" sort="Gantner, Dashiell" uniqKey="Gantner D" first="Dashiell" last="Gantner">Dashiell Gantner</name>
<name sortKey="Mcarthur, Colin" sort="Mcarthur, Colin" uniqKey="Mcarthur C" first="Colin" last="Mcarthur">Colin Mcarthur</name>
<name sortKey="Murray, Lynnette" sort="Murray, Lynnette" uniqKey="Murray L" first="Lynnette" last="Murray">Lynnette Murray</name>
<name sortKey="Presneill, Jeffrey" sort="Presneill, Jeffrey" uniqKey="Presneill J" first="Jeffrey" last="Presneill">Jeffrey Presneill</name>
<name sortKey="Rashford, Stephen" sort="Rashford, Stephen" uniqKey="Rashford S" first="Stephen" last="Rashford">Stephen Rashford</name>
<name sortKey="Rosenfeld, Jeffrey V" sort="Rosenfeld, Jeffrey V" uniqKey="Rosenfeld J" first="Jeffrey V" last="Rosenfeld">Jeffrey V. Rosenfeld</name>
<name sortKey="Stephenson, Michael" sort="Stephenson, Michael" uniqKey="Stephenson M" first="Michael" last="Stephenson">Michael Stephenson</name>
<name sortKey="Trapani, Tony" sort="Trapani, Tony" uniqKey="Trapani T" first="Tony" last="Trapani">Tony Trapani</name>
<name sortKey="Varma, Dinesh" sort="Varma, Dinesh" uniqKey="Varma D" first="Dinesh" last="Varma">Dinesh Varma</name>
<name sortKey="Walker, Tony" sort="Walker, Tony" uniqKey="Walker T" first="Tony" last="Walker">Tony Walker</name>
<name sortKey="Webb, Steve" sort="Webb, Steve" uniqKey="Webb S" first="Steve" last="Webb">Steve Webb</name>
</country>
<country name="France">
<region name="Bourgogne-Franche-Comté">
<name sortKey="Capellier, Gilles" sort="Capellier, Gilles" uniqKey="Capellier G" first="Gilles" last="Capellier">Gilles Capellier</name>
</region>
</country>
<country name="Nouvelle-Zélande">
<noRegion>
<name sortKey="Newby, Lynette" sort="Newby, Lynette" uniqKey="Newby L" first="Lynette" last="Newby">Lynette Newby</name>
</noRegion>
<name sortKey="Smith, Tony" sort="Smith, Tony" uniqKey="Smith T" first="Tony" last="Smith">Tony Smith</name>
</country>
</tree>
</affiliations>
</record>

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